Assistant Professor

Lab Introduction:

Cancer spread or metastasis is a dreaded word for any cancer patient and is the key determinant of cancer mortality or morbidity. Therapeutic approaches to treat metastatic cancers are limited due to a very complex and intricate nature of the signaling pathways that drive this process. Therefore, a better understanding of the metastatic process is probably needed to effeciently target and treat the disease. 

We use multidisciplinary approaches in our lab to understand molecular basis of cellular metastasis especially EMT switching and cancer cell survival. We are also interested in developing nanocomplex drug delivery systems for efficient and targeted therapies in cancer. We mostly rely on extramural grants for our research provided by  various national and international funding agencies.  Over the last few years our reserach has been funded by most of the funding bodies in india like UGC (2017), SERB (2018), CSIR (2020), and DBT (2022) 

Students/Scholars interested in this field of research are always welcome to apply for various positions that are available from time to time. They can reach us at  beighm@uok.edu.in to discuss and enquire about possible reearch positions.

 

Current Lab members:

Asma Rafiq (PhD Candidate)

Rabia Rakshan (PhD Candidate)

Mehvish Ali (PhD candidate)

Sarvar Hussain, Project JRF

(PhD candidate-Joint Supervision)

MSc Internship candidates (Batch 2022):

  1.  Zahida Akhter
  2. Mohsina Majeed

Faculty Details

  • Citations 727
  • HIndex 12
  • i10 Index 14
  • Email beighm@uok.edu.in
  • Administrative position Held Nodal Officer (DIQA)
  • Resume View



Research Papers Published

  • "SIX1 transcription factor: A review of cellular functions and regulatory dynamics" International Journal of Biological Macromolecules, 193(0): 1151 -1164 {ISSN: 0141-8130} Impact Factor= 8.025
  • "TGF-ß signaling: A recap of SMAD-independent and SMAD-dependent pathways" Journal of Cellular Physiology, 237(1): 59 -85 {ISSN: 0021-9541} Impact Factor= 6.384
  • "Electrospun polyurethane fiber mats coated with fish collagen layer to improve cellular affinity for skin repair" Sustainable Materials and Technologies, 34(0): 00523 -1 {ISSN: 2214-9929} Impact Factor= 10.6
  • "GSK3ß phosphorylates Six1 transcription factor and regulates its APC/CCdh1 mediated proteosomal degradation" Cellular Signaling, 115(1): DOI No. 111030 {ISSN: 0898-6568} Impact Factor= 4.8
  • "Optimizing the fabrication of electrospun nanofibers of prochlorperazine for enhanced dissolution and permeation properties" Biomaterials Advances, 158(1): DOI No. 213773 {ISSN: 2772-9508} Impact Factor= 7.9

Books Published

  • "Prospects of Natural Polymeric Scaffolds in Peripheral Nerve Tissue-regeneration. Novel biomaterials for regenerative medicine". Springer. {ISBN: 978-981-13-0947-2} pp 36
  • "Scaffolds fabricated from natural polymeric/composites by electrospinning for bone tissue regeneration". Springer. {ISBN: 978-981-13-0947-2} pp 32
  • "Incorporating Poorly Soluble Drugs into Electrospun Nanofibers for Improved Solubility and Dissolution Profile". Springer-Nature. {ISBN: 978-3-030-99958-2} pp 20
  • "Interaction of Nanomaterials With Living Cells". Springer,, Singapore. {ISBN: 978981992} pp 899

Research Projects Details:

Title of the ProjectFunding AgencyDatedAmount (in Rs.)
Regulatory dynamics of Grainyhead like 2 proteins (GRHL2): Implications in epithelial –mesenchymal transitionUGC04-12-20171,000,000.00
Facile nano-engineered polyurethane nanofibers incorporating titanium dioxide (TiO2) and silver (Ag) nanoparticles towards guided bone tissue-regeneration.SERB, DST10-03-20174,105,470.00
Nano-bio approach for tissue-engineered antimicrobial and wound healing Polyurethane nanofibers incorporating silver nanoparticles and essential oil lavender: fabrication and comparative studyDST, Nanomission06-03-20173,590,745.00
Phospho regulatory dynamics of Sine Oculis homeobox 1 (SIX1): Implications in generation of mesenchymal phenotypeSERB25-10-20184,668,200.00
Structural insights into the mechanism of Phosphoregulation of the Grainyhead like 2 proteins: Implications in breast cancer pathogenesis.CSIR, Govt. of India13-07-20212,800,000.00
Evaluation of GSK3ß/CK2/Six1 signaling axis as a potential therapeutic node in cancer metastasisDBT, GOI31-12-20225,523,000.00

Teaching:

DepartmentSubjectCourse TaughtSemester
NanotechnologyMasters in NanotechnologyAdvanced Techniques1
NanotechnologyMasters in NanotechnologyGenetic Engineering1
NanotechnologyMasters in NanotechnologyNanotechnology Laboratory Course-I2
NanotechnologyMasters in NanotechnologyHuman Physiology & Disease2
NanotechnologyMasters in NanotechnologyBionanoscience & Therapeutics2
NanotechnologyMasters in NanotechnologyTargeted drug delivery2
NanotechnologyMasters in NanotechnologyCancer nanotechnology3
NanotechnologyMasters in NanotechnologySeminar & Research Methodology3
NanotechnologyMasters in NanotechnologyNanotechnology Laboratory Course-II3
NanotechnologyMasters in NanotechnologyNanomedicine-I: Therapeutics & Diagnostics3